Dreadful Diseases

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Inheritance concerns the exact transmission of genetic information from parents to their progeny. Variability of the inherited characteristics can be accounted for by a change either in a genetic makeup of a cell or in environmental conditions. Deoxyribonuclic acid is responsible for heredity in all cells. It was identified as a compound bearings genetic information whwn in 1949 Avery, Maclead and McCarty discovered that a non-virulent strain of the bacterium Streptococcus Pneumoniae could be transformed in a heritable manner into a virulent strain by simply adding DNA extracted from a dead virulent strain in to the medium.

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It was only a little more than 100 years ago that first serious study of genetics was undertaken by Austrian Monk Gregor Mendel in his pea patch. He crossed strains of peas and studied the results of these crosses changes in color, shape, size and other properties of peas. He published his work entitled experiments with plant hybrids in 1865. The laws of heredity first formulated by Mendel are common to all forms of life. They apply to humans just as well as to the “lowly” bacterium. Genetics is the study of the inheritance (heredity) and the variability of the characteristics of an organism.

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In the first part the fundamentals of controls which are applicable when either physical or chemical methods are used. In the second part the physical agents and physical methods for reducing or eliminating the viable microbial population. Microorganisms are not simple physical targets. Many biological characteristics influence the rate at which microorganisms are killed or inactivated by various agents. Many factors must be considered in the application of any physical or chemical agent used to inhibit or destroy microbial populations. It is not possible to prescribe one agent that will be effective for the control of microorganisms for all materials and all circumstances. The physical and chemical substance would carry the organism.

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The term control as used here refers to the reduction in numbers and/or activity of the total microbial flora. The principal reasons for controlling microorganisms are to prevent transmission of disease and infection, to prevent contamination by or growth of undesirable microorganisms and to prevent deterioration and spoilage of materials by microorganisms. Microorganisms can be removed, inhibited or killed by various physical agents, physical process or chemical agents. A variety of techniques and agents are available. They act in many different ways and each has its own limit of application.

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Sanitizer is an agent that reduces the microbial population to safe levels as judged by public health requirements. Germicide is an agent that kills the growing forms but not necessarily the resistant spore forms of germs. Gemicides are commonly used for all kinds of germs. Bactericide is an agent that kills bacteria. The terms fungicide virucide & sporicide refer to agents that kills fungi, viruses and spores respectively. Bacteriostasis has a condition in which the growth of bacteria is prevented, fungistatic describes an agent that stops the growth of fungi. Antimicrobial agent which interferes with the growth and metabolism of microbes.